Protein Kinase G is a key regulator of murine white adipogenesis
نویسندگان
چکیده
Background Obesity, the excessive accumulation of adipose tissue, is the result of an imbalance in energy intake and output. Mammals posses two functionally distinct types of adipose tissue, namely white adipose tissue (WAT) and brown adipose tissue (BAT). In addition to its primary role for energy storage, WAT is a hormone and cytokine secreting organ involved in inflammatory responses. In contrast, BAT dissipates energy. Protein kinase G (PKGI) has been shown to be indispensable for smooth muscle cell relaxation and recently, we have demonstrated a crucial role for PKGI in BAT. In the present study, we investigated the role of PKGI in white adipocyte differentiation.
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2011